In the present paper, a numerical algorithm based on the finite element method is proposed for the prediction of the mechanical response of reinforced concrete (RC) beams under bending Water Tumbler loading.The main novelty of such an approach is the introduction of the Overlapping Crack Model, based on nonlinear fracture mechanics concepts, to des
The incidence of primary cutaneous melanoma continues to increase annually and is one of the most aggressive malignancies in humans and need to develop more novel non-surgical therapies.Autophagy and cathepsin B targeted therapy was reported to improve melanoma treatment.Cepharanthine (CEP), a natural alkaloid extracted from the genus Cephalophyllu
It is known that functions in a Sobolev space with critical exponent embed into the space of functions of bounded mean oscillation, and therefore satisfy the John-Nirenberg Water Tumbler inequality and a corresponding exponential integrability estimate.While these inequalities are optimal for general functions of bounded mean oscillation, the main